Comparison of antibacterial activity of a new cephalosporin, ceftizoxime (FK 749) with other cephalosporin antibiotics.
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چکیده
منابع مشابه
Antibacterial activity of ceftizoxime (FK 749), a new cephalosporin, against cephalosporin-resistant bacteria, and its stability to beta-lactamase.
Antibacterial activity of FK 749 against ampicillin-resistant clinical isolates of Escherichia coli was compared with those of other newly developed cephalosporins. FK 749 was the most active against strains possessing R-plasmids specifying ampicillin resistance and those whose resistance was chromosomally determined. The susceptibility of ampicillin-susceptible E. coli to FK 749 was not decrea...
متن کاملCeftizoxime (FK 749), a new parenteral cephalosporin: in vitro and in vivo antibacterial activities.
FK 749 is a new parenteral cephalosporin derivative which is more active against various gram-negative bacilli, including the opportunistic pathogens such as Enterobacter, Citrobacter species, and Serratia marcescens, than cephalosporins and cephamycins such as cefotiam, cefamandole, cefuroxime, cefotaxime, and cefmetazole. FK 749 was especially active against gram-negative organisms resistant ...
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(pyrazol-3-yl)pyridmium group at the C-3' position as a combination of the pyridine moiety of ceftazidime2) and the pyrazole moiety of cefoselis3) to attain a synergic effect in activity. As we expected, those compoundsexhibited wellbalanced and broad spectrum of activity against Grampositive and Gram-negative bacteria. Of them, 7-[(Z)-2-(2aminol ,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3[(3...
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Vol. 23: Fundamentals in Cancer Chemotherapy. Anticancer Symposium held in Connection with the 10th International Congress of Chemotherapy, Zurich, September 1977. Ed.: F. M. SCHABEL, Jr. (Birmingham, Ala.). VIII +3 04 p., 62 fig., 1 cpl., 91 tab., 1978 ISBN 3-8055-2830-2 Vol. 24: Application of Cancer Chemotherapy. Anticancer Symposium held in Connection with the 10th International Congress of...
متن کاملFK037, a new parenteral cephalosporin with a broad antibacterial spectrum: synthesis and antibacterial activity.
Sir: In recent years, a number of new parenteral cephalosporins with a broad spectrum of antibacterial activity and a high stability against various /Mactamases have been reported1}. Most of them have a 7j5-[(Z)-2-(2-aminothiazol-4-yl)-2-alkoxyiminoacetamido] side chain, such as ceftizoxime (CZX) and ceftazidime (CAZ). They show excellent activity against Gram-negative bacteria and moderate act...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1979
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.32.1319